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In an embodiment, the 8-substituted tetracycline compound is 8-substituted tetracycline (eg, wherein R 4 is NR 4′R 4″; R 4′ and R 4″ are methyl, R 5 is hydrogen and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydroxy); 8-substituted doxycycline (eg, wherein R 4 is NR 4′R 4″; R 4′ and R 4″ are methyl, R 5 is hydroxyl and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydrogen); or 8-substituted sancycline (wherein R 4 is NR 4′R 4″; R 4′ and R 4″ are methyl; R 5 is hydrogen and X is CR 6R 6″ wherein R 6 and R 6′ are hydrogen atoms? Meldonium und seine Metaboliten passieren teilweise die Plazentaschranke, empagliflozin cost
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